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“哈灵生物”产品文献:Science of The Total Environment

?Science of The Total Environment

Volumes 622–623, 1 May 2018, Pages 214-221
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Developmental and metabolic responses of zebrafish (Danio rerio) embryos and?
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larvae to short-chain chlorinated paraffins (SCCPs) exposure
Author links open overlay?
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panelXiaoqianRenabHaijunZhangaNingboGengaLiguoXingcYuZhaocFeidiWangabJipingChe
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na
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https://doi.org/10.1016/j.scitotenv.2017.11.304Get rights and content
Highlights
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Effects of SCCPs on development and metabolism of zebrafish were evaluated.
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SCCPs were highly toxic to zebrafish larvae, with 13-day LC50 value of 34.4?
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μg/L.
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Low-dose SCCPs slightly disturbed the overall metabolism in zebrafish embryos.
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SCCPs mainly disturbed metabolisms of glycerophospholipids, fatty acids and?
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purine.
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Abstract
Short-chain chlorinated paraffins (SCCPs) are highly toxic to aquatic?
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organisms, but their toxicity is yet not well characterized. In this study,?
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the developmental toxicity of SCCPs to zebrafish embryos/larvae was evaluated,?
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and a metabolomics approach was adopted to explore the impact of SCCPs?
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exposure on the metabolism in zebrafish embryos. Exposure to SCCPs at?
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concentrations of 1–200 μg/L did not produce an observable effect on the?
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hatching rate and morphological deformities of zebrafish embryos/larvae.?
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However, the survival rate of zebrafish larvae in SCCPs exposure groups?
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decreased in a concentration-dependent manner. The 13-day 50% lethal?
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concentration (LC50) value of SCCPs was calculated to be 34.4 μg/L. Exposure?
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to SCCPs induced a significant change of overall metabolism, even at?
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environmentally relevant concentrations (1–5 μg/L). The most relevant?
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pathways affected by SCCPs exposure were glycerophospholipid metabolism, fatty?
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acid metabolism and purine metabolism. Exposure to SCCPs at concentrations of?
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1–5 μg/L had begun to accelerate the β-oxidation of unsaturated fatty acids?
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and very long chain fatty acids, and affect the transformation of guanine to?
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xanthine in the pathway of purine metabolism. Furthermore, when the exposure?
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concentrations of SCCPs were increased to 50–200 μg/L, the levels of?
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phospholipids and amino acids were significantly raised; whereas the levels of?
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fatty acids, carnitines and inosine were significantly decreased. In view of?
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the significant effect on metabolism, the sub-chronic and chronic toxicity of?
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SCCPs to fish should be concerned.
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Graphical abstract
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Keywords
Short-chain chlorinated paraffinsZebrafish?
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embryo/larvaeMetabolomicsDevelopmental toxicity
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